1. Forde JE，Dale TC.Glycogen synthase kinase 3：a key regulator of cellular fate.Cell Mol Life Sci，2007，64（15）：1930-1944.

2. Rayasam GV，Tulasi VK，Sodhi R，Davis JA，Ray A.Glycogen synthase kinase 3：more than a namesake.Br J Pharmacol，2009，156（6）：885-898.

3.李桂源.病理生理学.北京：人民卫生出版社，2010：31-41，248-60，291-302.

4. Wang Q，Cheng Y，Xue FS，et al.Postconditioning with vagal stimulation attenuates local and systemic inflammatory responses to myocardial ischemia reperfusion injury in rats.Inflamm Res，2012，61（11）：1273-1282.

5. Xiong J，Yuan YJ，Xue FS，et al. Postconditioning with α7nAChR agonist attenuates systemic inflammatory response to myocardial ischemia-reperfusion injury in rats.Inflammation，2012，35（4）：1357-1364.

6. Schwabe RF，Brenner DA.Role of glycogen synthase kinase-3 in TNF-α-induced NF-κB activation and apoptosis in hepatocytes.Am J Physiol Gastrointest Liver Physiol，2002，283 （1）：G204-211.

7. Wang H，Brown J，Martin M.Glycogen synthase kinase 3：a point of convergence for the host inflammatory response.Cytokine，2011，53（2）：130-40.

8. Shen E，Fan J，Peng T.Glycogen synthase kinase-3β suppresses tumor necrosis factor-α expression in cardiomyocytes during lipopolysaccharide stimulation.J Cell Biochem，2008，104（1）：329-338.

9. Ha T，Hu Y，Liu L，et al.TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/ Akt-dependent mechanism. Cardiovasc Res，2010，87（4）：694-703.

10. Gao HK，Yin Z，et al.GSK-3β inhibitor modulates TLR2/ NF-κB signaling following myocardial ischemia reperfusion. Inflamm Res，2009，58（7）：377-83.

11. Rasola A，Bernardi P.The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis.Apoptosis，2007，12（5）：815-33.

12. Juhaszova M，Zorov DB，Kim SH，Pepe S et al. Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore.J Clin Invest，2004，113（11）：1535-1549.

13. Gomez L，Paillard M，Thibault H，et al.Inhibition of GSK3β by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion.Circulation，2008，117（21）：2761-2768.

14. Miyamoto S，Murphy AN，Brown JH.Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II.Cell Death Differ，2008，15 （3）：521-529.

15. Pastorino JG，Hoek JB，Shulga N. Activation of glycogen synthase kinase 3β disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer Res，2005，65（22）：10545-10554.

16. Nishihara M，Miura T，Miki T，Tanno M et al.Modulation of the mitochondrial permeability transition pore complex in GSK-3β-mediated myocardial protection.J Mol Cell Cardiol，2007，43（5）：564-570.

17. Watcharasit P，Bijur GN，Song L，et al.Glycogen synthase kinase-3β（GSK3β）binds to and promotes the actions of p53.J Biol Chem，2003，278（49）：48872-48879.

18. Venkatapuram S，Wang C，Krolikowski JG，et al.Inhibition of apoptotic protein p53 lowers the threshold of isofluraneinduced cardioprotection during early reperfusion in rabbits. Anesth Analg，2006，103（6）：1400-1405.

19. Das S，Wong R，Rajapakse N，et al.Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation.Circ Res，2008，103（9）：983-991.

20. Watcharasit P，Bijur GN，Song L，et al.Glycogen synthase kinase-3β（GSK3β）binds to and promotes the actions of p53.J Biol Chem，2003，278（49）：48872-48879.

21. O’Driscoll C，Wallace D，Cotter TG.bFGF promotes photoreceptor cell survival in vitro by PKA-mediated inactivation of glycogen synthase kinase 3β and CREB-dependent Bcl-2 up-regulation.J Neurochem，2007，103（3）：860-870.

22. Kaga S，Zhan L，Altaf E，et al. Glycogen synthase-3β/βcatenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF，Bcl-2 and survivin expression in rat ischemic preconditioned myocardium.J Mol Cell Cardiol，2006，40（1）：138-147.

23. Wu QL，Shen T，Shao LL，et al.Ischemic postconditioning mediates cardioprotection via PI3K/GSK-3β/β-catenin signaling pathway in ischemic rat myocardium.Shock，2012，38 （2）：165-169.

24. Li J，Xuan W，Yan R，et al.Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin. Clin Sci （Lond），2011，120（10）：451-462.

25. Obame FN，Plin-Mercier C，Assaly R，Zini R，et al.Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3β，SB216763［3-（2，4-dichlorophenyl）-4（1-methyl-1H-indol-3-yl）-1H-pyrrole-2，5-dione］，via inhibition of the mitochondrial permeability transition pore. J Pharmacol Exp Ther，2008，326（1）：252-258.

26. Wu QL，Shen T，Ma H，et al. Sufentanil postconditioning protects the myocardium from ischemia-reperfusion via PI3K/Akt-GSK-3β pathway. J Surg Res，2012，178（2）：563-570.

27. Mio Y，Shim YH，Richards E，et al.Xenon preconditioning：the role of prosurvival signaling，mitochondrial permeability transition and bioenergetics in rats.Anesth Analg，2009，108 （3）：858-866.

28. Fang NX，Yao YT，Shi CX，et al.Attenuation of ischemiareperfusion injury by sevoflurane postconditioning involves protein kinase B and glycogen synthase kinase 3β activation in isolated rat hearts. Mol Biol Rep，2010，37（8）：3763-3769.

29. Ghaboura N，Tamareille S，Ducluzeau PH，Grimaud L et al. Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signaling. Basic Res Cardiol，2011，106（1）：147-162.

30. Yadav HN，Singh M，Sharma PL.Involvement of GSK-3β in attenuation of the cardioprotective effect of ischemic preconditioning in diabetic ratheart.Mol Cell Biochem，2010，343（1-2）：75-81.

31. Gross ER，Hsu AK，Gross GJ.Diabetes abolishes morphineinduced cardioprotection via multiple pathways upstream of glycogen synthase kinase-3β.Diabetes，2007，56（1）：127-136.

32. Tai W，Shi E，Yan L，et al.Diabetes abolishes the cardioprotection induced by sevoflurane postconditioning in the rat heart in vivo：roles of glycogen synthase kinase-3β and its upstream pathways.J Surg Res，2012，178（1）：96-104.

33. Ghaboura N，Tamareille S，Ducluzeau PH，et al. Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signaling.Basic Res Cardiol，2011，106（1）：147-162.

34. Yadav HN，Singh M，Sharma PL.Modulation of the cardioprotective effect of ischemic preconditioning in hyperlipidaemic rat heart.Eur J Pharmacol，2010，643（1）：78-83.

35. Yadav HN，Singh M，Sharma PL.Pharmacological inhibition of GSK-3β produces late phase of cardioprotection in hyperlipidemic rat：possible involvement of HSP72.Mol Cell Biochem，2012，369（1-2）：227-233.

36. Wagner C，Ebner B，Tillack D，et al.Cardioprotection by ischemic postconditioning is abrogated in hypertrophied myocardium of spontaneously hypertensive rats. J Cardiovasc Pharmacol，2013，61（1）：35-41.

37. Zhu J，Rebecchi MJ，Tan M，et al. Age-associated differences in activation of Akt/GSK-3β signaling pathways and inhibition of mitochondrial permeability transition pore opening in the rat heart.J Gerontol A Biol Sci Med Sci，2010，65（6）：611-619.

38. Zhu J，Rebecchi MJ，Glass PS，et al.Cardioprotection of the aged rat heart by GSK-3β inhibitor is attenuated：age-related changes in mitochondrial permeability transition pore modulation.Am J Physiol Heart Circ Physiol，2011，300 （3）：H922-930.