Acknowledgment

I greatly appreciate Profs. Jinfa Jiang, Wenju Xu, Xianghua Yi, Haiying Wan from Tongji Hospital of Tongji University for data collection and detection. I also give thanks to Prof.Yu Zhang from electron microscopy center of Fudan Univserity, Profs. Hengjun Gao and Xiaoying Shen from South Gene Chip Center for their platform. Profs. Huikang Zhao and Jing Chen made great effort in image production. Guanghe Li helped to edit the draft. Many thanks should also be given to my parents, my wife and friends. Finally,I specially appreciate Dr. Qianglin Duan, Prof. Shulin Liu and Prof. Anthony Dart.Monash University, Australia.for their kind help in English usage.