Preface

The aim of this book is to summarize research data, which support a central role of alterations in immune functions in thrombosis development. Whilst venous (red) and arterial (white) thrombi differ histologically, their upstream initiating factors are similar.Venous thrombi, whether familial or acquired, result from a defensive mechanism to prevent the passage of intravenous microorganisms or malignant cells by the formation of biological filters. Such filters then also trap red blood cells, hence resulting in typical venous red thrombosis. Arterial thrombosis results from endothelial damage leading to platelet adhesion. The rupture of the atherosclerosis soft plaque cap and superficial anabrotic damage to the endothelium may result from the effects of reactive oxygen species or cytokines released from neutrophils activated in response to the microorganisms that have entered the bloodstream following the collapse of the immune cell balance function. Thus venous thrombosis results from activation of the body's new defensive mechanism, whilst arterial thrombosis results from a failure of defensive mechanism to clear pathogens.

This book brings together extensive studies of the author conducted over the past couple of decades into the origins and pathogenesis of thrombosis with publications in a range of leading international journals. We have conducted studies in a variety of clinical groups and on different experimental models, using a range of technical approaches including genomics, proteomics, immunology, microbiology and cytology. We also analyzed internal and external causes of acquired and familiar venous thrombosis and proposed origin and onset of venous thrombus diseases and its triggering factors. Based on genomics and immunocytological research findings, we proposed collapsed immune cell balance function as the origin of arterial thrombus diseases and concluded that exogenous microorganisms may be the triggering factor of arterial thrombosis.

The recognition of natural phenomena originates from curiosity and observation,gradually from shallower to the deeper and from the surface to the center, rising spirally.It is the same with recognizing diseases. However, it is the development of the times that provides the possibility to understand the micro structures and functions of diseases.“The origin and onset of thrombus Diseases” welcomes any comments, suggestions or criticisms from readers with common interest in research or clinical areas.

This book is dedicated to all graduate students of our thrombosis research team. Their multi-dimensional perspective work verifies the origin and onset of thromboembolic disease and its immune mechanism. The team members includes: Dr.Fan Yang, Dr. Qianglin Duan, Dr. Wei Lv, Dr. Zhu Gong, Dr. Haoming Song, Dr. Lin Zhou, Dr. Yanli Song, Dr. Wenwen Yan, Dr. Hao Wang, Dr. Qiang Wang, Dr. Guiyuan Li, Dr. Yun Jin, Dr. Siwan Wen, Dr. Zhiru Ge, Dr. Kebin Cheng, Dr.Mei Fu, Dr. Xiaoyu Zhang, Dr. Chunyu Huang, Dr. Yuan Xie, Dr.Jinghua Tan, Dr. Qi Yu, Dr. Yixin Chen,Dr. Chuanrong Li.