参考文献

[1]SCHWARTZ P J，SPAZZOLINI C，CROTTI L，et al.The Jervell and Lange-Nielsen syndrome：natural history，molecular basis，and clinical outcome.Circulation，2006，113（6）：783-790.

[2]SCHWARTZ P J，CROTTI L，INSOLIA R，et al.Long-QT syndrome：from genetics to management.Circ Arrhythm Electrophysiol，2012，5（4）：868-877.

[3]KAPPLINGER J D，TESTER D J，SALISBURY B A，et al.Spectrum and prevalence of mutations from the first 2 500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test.Heart Rhythm，2009，6（4）：1297-1303.

[4]VANDENBERG J I，PERRY M D，PERRIN M J，et al.hERG K（+）channels：structure，function，and clinical significance.Physiol Rev，2012，92（3）：1393-1478.

[5]ZHANG X D，LIEU D K，CHIAMVIMONVAT N，et al.Small-conductance Ca2+-activated K+channels and cardiac arrhythmias.Heart Rhythm，2015，12（8）：1845-1851.

[6]JIANG Y Y，HOU H T，YANG Q，et al.Chloride Channels are Involved in the Development of Atrial Fibrillation-A Transcriptomic and proteomic Study.Sci Rep，2017，7（1）：10215.

[7]ZHANG Y，LIAO J，ZHANG L，et al.BK（Ca）channel activity and vascular contractility alterations with hypertension and aging via β1 subunit promoter methylation in mesenteric arteries.Hypertens Res，2018，41（2）：96-103.

[8]NATTEL S，BURSTEIN B，DOBREV D，et al.Atrial remodeling and atrial fibrillation：mechanisms and implications.Circ Arrhythm Electrophysiol，2008，1（1）：62-73.

[9]TEMPLIN C，GHADRI J R，ROUGIER J S，et al.Identification of a novel loss-of-functioncalcium channel gene mutation in short QT syndrome（SQTS6）.Eur Heart J，2011，32（9）：1077-1088.

[10]KANG G，GIOVANNONE S F，LIU N，et al.Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsiwe to targeted therapy.Circ Res，2010，107（4）：512-519.