1. Benigni A，Cassis P，Remuzzi G.Angiotensin II revisited：new roles in inflammation，immunology and aging. EMBO Mol Med，2010，2（7）：247-257.

2. Vukelic S，Griendling KK.Angiotensin II，from vasoconstrictor to growth factor：a paradigm shift. Circ Res，2014，114 （5）：754-757.

3. Foulquier S，Steckelings UM，Unger T.Perspective：a tale of two receptors.Nature，2013，493（7434）：S9.

4. Qi Y，Katovich MJ.Is angiotensin II type 2 receptor a new therapeutic target for cardiovascular disease？Exp Physiol，2014，99（7）：933-934.

5. Namsolleck P，Recarti C，Foulquier S，et al.AT（2）receptor and tissue injury：therapeutic implications. Curr Hypertens Rep，2014，16（2）：416.

6. Soliman S，Ishrat T，Pillai A，et al. Candesartan induces a prolonged proangiogenic effect and augments endotheliummediated neuroprotection after oxygen and glucose deprivation：role of vascular endothelial growth factors A and B.J Pharmacol Exp Ther，2014，349（3）：444-457.

7. Tsuneki H，Tokai E，Suzuki T，et al.Protective effects of coenzyme Q10 against angiotensin II-induced oxidative stress in human umbilical vein endothelial cells.Eur J Pharmacol，2013，701（1-3）：218-227.

8. Wang Y，Li Y，Wu Y，et al.TNF-α and IL-1β neutralization ameliorates angiotensin II-induced cardiac damage in male mice.Endocrinology，2014，155（7）：2677-2687.

9. Dai Q，Xu M，Yao M，et al.Angiotensin AT1 receptor antagonists exert anti-inflammatory effects in spontaneously hypertensive rats.Br J Pharmacol，2007，152（7）：1042-1048.

10. Urushihara M，Ohashi N，Miyata K，et al.Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis. Hypertension，2011，57（3）：586-593.

11. Sun P，Zhang W，Zhu W，et al.Expression of renin-angiotensin system on dendritic cells of patients with coronary artery disease.Inflammation，2009，32（6）：347-356.

12. Liu J，Zhang PS，Yu Q，et al.Losartan inhibits conventional dendritic cell maturation and Th1 and Th17 polarization responses：Νovel mechanisms of preventive effects on lipopolysaccharide-induced acute lung injury. Int J Mol Med，2012，29（2）：269-276.

13. Hermansson C，Lundqvist A，Magnusson LU，et al.Macrophage CD14 expression in human carotid plaques is associated with complicated lesions，correlates with thrombosis，and is reduced by angiotensin receptor blocker treatment. Int Immunopharmacol，2014，22（2）：318-323.

14. Ma LJ，Corsa BA，Zhou J，et al.Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity.Am J Physiol Renal Physiol，2011，300（5）：F1203-1213.

15. Uchida HA，Kristo F，Rateri DL，et al.Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice. Atherosclerosis，2010，211（2）：399-403.

16. Marvar PJ，Vinh A，Thabet S，et al.T lymphocytes and vascular inflammation contribute to stress-dependent hypertension.Biol Psychiatry，2012，71（9）：774-782.

17. Madhur MS，Lob HE，McCann LA，et al.Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction.Hypertension，2010，55（2）：500-507.

18. Barhoumi T，Kasal DA，Li MW，et al.T regulatory lymphocytes prevent angiotensin II-induced hypertension and vascular injury.Hypertension，2011，57（3）：469-476.

19. Jerng JS，Hsu YC，Wu HD，et al.Role of the renin-angiotensin system in ventilator-induced lung injury：an in vivo study in a rat model.Thorax，2007，62（6）：527-535.

20. Jiang JS，Wang LF，Chou HC，et al.Angiotensin-converting enzyme inhibitor captopril attenuates ventilator-induced lung injury in rats.J Appl Physiol（1985），2007，102（6）：2098-2103.

21. Yao S，Feng D，Wu Q，et al.Losartan attenuates ventilatorinduced lung injury.J Surg Res，2008，145（1）：25-32.

22. Liu L，Qiu HB，Yang Y，et al.Losartan，an antagonist of AT1 receptor for angiotensin II，attenuates lipopolysaccharide-induced acute lung injury in rat. Arch Biochem Biophys，2009，481（1）：131-136.

23. Shen L，Mo H，Cai L，et al.Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappa B and mitogen-activated protein kinases. Shock，2009，31（5）：500-506.

24. Podowski M，Calvi C，Metzger S，et al.Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice.J Clin Invest，2012，122（1）：229-240.

25. Tanaka J，Tajima S，Asakawa K，et al.Preventive effect of irbesartan on bleomycin-induced lung injury in mice.Respir Investig，2013，51（2）：76-83.

26. Yang J，Tan Y，Zhao F，et al.Angiotensin II plays a critical role in diabetic pulmonary fibrosis most likely via activation of NADPH oxidase-mediated nitrosative damage. Am J Physiol Endocrinol Metab，2011，301（1）：E132-144.

27. Platten M，Youssef S，Hur EM，et al.Blocking angiotensinconverting enzyme induces potent regulatory T cells and modulates TH1-and TH17-mediated autoimmunity. Proc Natl Acad Sci U S A，2009，106（35）：14948-14953.

28. Stegbauer J，Lee DH，Seubert S，et al.Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system.Proc Natl Acad Sci USA，2009，106（35）：14942-14947.

29. Sagawa K，Nagatani K，Komagata Y，et al.Angiotensin receptor blockers suppress antigen-specific T cell responses and ameliorate collagen-induced arthritis in mice.Arthritis Rheum，2005，52（6）：1920-1928.

30. Price A，Lockhart JC，Ferrell WR，et al.Angiotensin II type 1 receptor as a novel therapeutic target in rheumatoid arthritis：in vivo analyses in rodent models of arthritis and ex vivo analyses in human inflammatory synovitis. Arthritis Rheum，2007，56（2）：441-447.

31. Perry ME，Chee MM，Ferrell WR，et al.Angiotensin receptor blockers reduce erythrocyte sedimentation rate levels in patients with rheumatoid arthritis.Ann Rheum Dis，2008，67 （11）：1646-1647.

32. Refaat R，Salama M，Abdel Meguid E，et al.Evaluation of the effect of losartan and methotrexate combined therapy in adjuvant-induced arthritis in rats.Eur J Pharmacol，2013，698（1-3）：421-428.

33. Kaschina E，Grzesiak A，Li J，et al.Angiotensin II type 2 receptor stimulation：a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction？Circulation，2008，118（24）：2523-2532.

34. Lauer D，Slavic S，Sommerfeld M，et al.Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor β1 in the rat heart. Hypertension，2014，63（3）：e60-67.

35. Habashi JP，Doyle JJ，Holm TM，et al.Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.Science，2011，332（6027）：361-365.

36. Kljajic ST，Widdop RE，Vinh A，et al.Direct AT2 receptor stimulation is athero-protective and stabilizes plaque in Apolipoprotein E-deficient mice. Int J Cardiol，2013，169 （4）：281-287.

37. Nataatmadja M，Passmore M，Russell FD，et al.Angiotensin receptors as sensitive markers of acute bronchiole injury after lung transplantation.Lung，2014，192（4）：563-569.

38. Waseda Y，Yasui M，Nishizawa Y，et al.Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice.Respir Res，2008，9：43.

39. Imai Y，Kuba K，Rao S，et al.Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature，2005，436（7047）：112-116.

40. Wagenaar GT，Laghmani el H，Fidder M，et al.Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol，2013，305（5）：L341-351.

41. Wagenaar GT，Sengers RM，Laghmani el H，et al.Angiotensin II type 2 receptor ligand PD123319 attenuates hyperoxia-induced lung and heart injury at a low dose in newborn rats.Am J Physiol Lung Cell Mol Physiol，2014，307（3）：L261-272.

42. Curato C，Slavic S，Dong J，et al.Identification of noncytotoxic and IL-10-producing CD8+AT2R+T cell population in response to ischemic heart injury. J Immunol，2010，185 （10）：6286-6293.

43. Wang D，Hu SS，Zhu J，et al.AngiotensinⅡtype 2 receptor correlates with therapeutic effects of losartan in rats with adjuvant-induced arthritis.J Cell Mol Med，1577-1587.