1. Toblin RL，Mack KA，Perveen G，et al.A population-based survey of chronic pain and its treatment with prescription drugs.Pain，2011，152（6）：1249-1255.

2. Xin W，Chun W，Ling L，et al.Role of melatonin in the prevention of morphine-induced hyperalgesia and spinal glial activation in rats：protein kinase C pathway involved. Int J Neurosci，2012，122（3）：154-163.

3. Fishman SM，Ballantyne JC，Rathmell JP.Bonica’s Management of Pain.Philadelphia，Lippincott Williams＆Wilkins，2010.

4. Hutchinson MR，Shavit Y，Grace PM，et al. Exploring the neuroimmunopharmacology of opioids：an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia.Pharmacol Rev，2011，63（3）：772-810.

5. Song L，Wang S，Zuo Y，et al.Midazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury.Brain Res，2014，1564：52-61.

6.宋莉，杨邦祥，银燕，等.慢性吗啡注射对幼年大鼠痛行为学的影响.四川大学校报（医学版），2013，44（2）：668-671.

7. Wang S，Lim G，Yang L，et al.A rat model of unilateral hindpaw burn injury：slowly developing rightwards shift of the morphine dose-response curve.Pain，2005，116（1-2）：87-95.

8. Cao F，Gao F，Xu AJ，et al.Regulation of spinal neuroimmune responses by prolonged morphine treatment in a rat model of cancer induced bone pain.Brain Res，2010，1326：162-173.

9. He L，Kim JA，Whistler JL.Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor.Faseb J，2009，23（12）：4327-4334.

10. Dang VC，Chieng B，Azriel Y，et al.Cellular morphine tolerance produced by betaarrestin-2-dependent impairment of mu-opioid receptor resensitization. J Neurosci，2011，31 （19）：7122-7130.

11. Bailey CP，Llorente J，Gabra BH，et al.Role of protein kinase C and mu-opioid receptor（MOPr）desensitization in tolerance to morphine in rat locus coeruleus neurons.Eur J Neurosci，2009，29（2）：307-318.

12. Hu F，Cui Y，Guo R，et al.Spinal leptin contributes to the development of morphine antinociceptive tolerance by activating the STAT3-NMDA receptor pathway in rats.Mol Med Rep，2014，10（2）：923-930.

13. Berta T，Liu YC，Xu ZZ，et al.Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1beta and ERK signaling in the spinal cord of mice.Neuroscience，2013，247：376-385.

14. Shen CH，Tsai RY，Wong CS.Role of neuroinflammation in morphine tolerance：effect of tumor necrosis factor-alpha. Acta Anaesthesiol Taiwan，2012，50（4）：178-182.

15. Wen ZH，Wu GJ，Hsu LC，et al.N-Methyl-D-aspartate receptor antagonist MK-801 attenuates morphine tolerance and associated glial fibrillary acid protein up-regulation：a proteomic approach. Acta Anaesthesiol Scand，2008，52 （4）：499-508.

16. Kam AY，Liao D，Loh HH，et al.Morphine induces AMPA receptor internalization in primary hippocampal neurons via calcineurin-dependent dephosphorylation of GluR1 subunits.J Neurosci，2010，30（45）：15304-16.

17. Gabra BH，Bailey CP，Kelly E，et al.Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice.Brain Res，2008，1217：70-77.

18. Wang S，Tian Y，Song L，et al.Exacerbated mechanical hyperalgesia in rats with genetically predisposed depressive behavior：role of melatonin and NMDA receptors. Pain，2012，153（12）：2448-2457.

19. Gwak YS，Hulsebosch CE.GABA and central neuropathic pain following spinal cord injury.Neuropharmacology，2011，60（5）：799-808.

20. Bao YH，Zhou QH，Chen R，et al. Gabapentin attenuates morphine tolerance through interleukin-10. Neuroreport，2014，25（2）：71-76.

21. Lilius TO，Jokinen V，Neuvonen MS et al.Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat.Br J Pharmacol，2014.（online）